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e sis3  (MedChemExpress)


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    MedChemExpress e sis3
    E Sis3, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 114 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/e sis3/product/MedChemExpress
    Average 95 stars, based on 114 article reviews
    e sis3 - by Bioz Stars, 2026-03
    95/100 stars

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    ( A ) LINC00313 expression in HuCCT1 and Huh28 cells treated with LY2157299 or DMSO, and stimulated with TGFβ1 or BSA/HCl for 16 h. ( B ) LINC00313 and SERPINE1 expression in HuCCT1 and Huh28 treated with <t>SIS3</t> or DMSO and stimulated with TGFβ1 or BSA/HCl for 16 h. ( C ) LINC00313 expression in HuCCT1 transiently transfected with siRNA targeting SMAD2 , <t>SMAD3</t> , or SMAD4 , alone or in combination, with or without TGFβ1. ( D ) LINC00313 expression in Huh28 transiently transfected with siRNA targeting SMAD2 , SMAD3 , or SMAD4 , alone or in combination, with or without TGFβ1. ( E ) Snapshot of the UCSC genome browser showing predicted SMAD-binding regions in LINC00313 gene locus, using the JASPAR CORE 2022 collection. Active histone mark (H3K27ac) is also shown around LINC00313 TSS. Data information: Data are presented as mean ± SD ( n = 3 biological replicates). * P ≤ 0.05, ** P ≤ 0.01, *** P ≤ 0.001 (Student’s t -test), n.s.: not significant. In panel ( A ) the experiment in HuCCT1 cells was performed twice ( n = 2 biological replicates) and data are presented as single data points. .
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    ( A ) LINC00313 expression in HuCCT1 and Huh28 cells treated with LY2157299 or DMSO, and stimulated with TGFβ1 or BSA/HCl for 16 h. ( B ) LINC00313 and SERPINE1 expression in HuCCT1 and Huh28 treated with <t>SIS3</t> or DMSO and stimulated with TGFβ1 or BSA/HCl for 16 h. ( C ) LINC00313 expression in HuCCT1 transiently transfected with siRNA targeting SMAD2 , <t>SMAD3</t> , or SMAD4 , alone or in combination, with or without TGFβ1. ( D ) LINC00313 expression in Huh28 transiently transfected with siRNA targeting SMAD2 , SMAD3 , or SMAD4 , alone or in combination, with or without TGFβ1. ( E ) Snapshot of the UCSC genome browser showing predicted SMAD-binding regions in LINC00313 gene locus, using the JASPAR CORE 2022 collection. Active histone mark (H3K27ac) is also shown around LINC00313 TSS. Data information: Data are presented as mean ± SD ( n = 3 biological replicates). * P ≤ 0.05, ** P ≤ 0.01, *** P ≤ 0.001 (Student’s t -test), n.s.: not significant. In panel ( A ) the experiment in HuCCT1 cells was performed twice ( n = 2 biological replicates) and data are presented as single data points. .
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    ( A ) LINC00313 expression in HuCCT1 and Huh28 cells treated with LY2157299 or DMSO, and stimulated with TGFβ1 or BSA/HCl for 16 h. ( B ) LINC00313 and SERPINE1 expression in HuCCT1 and Huh28 treated with <t>SIS3</t> or DMSO and stimulated with TGFβ1 or BSA/HCl for 16 h. ( C ) LINC00313 expression in HuCCT1 transiently transfected with siRNA targeting SMAD2 , <t>SMAD3</t> , or SMAD4 , alone or in combination, with or without TGFβ1. ( D ) LINC00313 expression in Huh28 transiently transfected with siRNA targeting SMAD2 , SMAD3 , or SMAD4 , alone or in combination, with or without TGFβ1. ( E ) Snapshot of the UCSC genome browser showing predicted SMAD-binding regions in LINC00313 gene locus, using the JASPAR CORE 2022 collection. Active histone mark (H3K27ac) is also shown around LINC00313 TSS. Data information: Data are presented as mean ± SD ( n = 3 biological replicates). * P ≤ 0.05, ** P ≤ 0.01, *** P ≤ 0.001 (Student’s t -test), n.s.: not significant. In panel ( A ) the experiment in HuCCT1 cells was performed twice ( n = 2 biological replicates) and data are presented as single data points. .
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    ( A ) LINC00313 expression in HuCCT1 and Huh28 cells treated with LY2157299 or DMSO, and stimulated with TGFβ1 or BSA/HCl for 16 h. ( B ) LINC00313 and SERPINE1 expression in HuCCT1 and Huh28 treated with SIS3 or DMSO and stimulated with TGFβ1 or BSA/HCl for 16 h. ( C ) LINC00313 expression in HuCCT1 transiently transfected with siRNA targeting SMAD2 , SMAD3 , or SMAD4 , alone or in combination, with or without TGFβ1. ( D ) LINC00313 expression in Huh28 transiently transfected with siRNA targeting SMAD2 , SMAD3 , or SMAD4 , alone or in combination, with or without TGFβ1. ( E ) Snapshot of the UCSC genome browser showing predicted SMAD-binding regions in LINC00313 gene locus, using the JASPAR CORE 2022 collection. Active histone mark (H3K27ac) is also shown around LINC00313 TSS. Data information: Data are presented as mean ± SD ( n = 3 biological replicates). * P ≤ 0.05, ** P ≤ 0.01, *** P ≤ 0.001 (Student’s t -test), n.s.: not significant. In panel ( A ) the experiment in HuCCT1 cells was performed twice ( n = 2 biological replicates) and data are presented as single data points. .

    Journal: EMBO Reports

    Article Title: TGFβ-induced long non-coding RNA LINC00313 activates Wnt signaling and promotes cholangiocarcinoma

    doi: 10.1038/s44319-024-00075-z

    Figure Lengend Snippet: ( A ) LINC00313 expression in HuCCT1 and Huh28 cells treated with LY2157299 or DMSO, and stimulated with TGFβ1 or BSA/HCl for 16 h. ( B ) LINC00313 and SERPINE1 expression in HuCCT1 and Huh28 treated with SIS3 or DMSO and stimulated with TGFβ1 or BSA/HCl for 16 h. ( C ) LINC00313 expression in HuCCT1 transiently transfected with siRNA targeting SMAD2 , SMAD3 , or SMAD4 , alone or in combination, with or without TGFβ1. ( D ) LINC00313 expression in Huh28 transiently transfected with siRNA targeting SMAD2 , SMAD3 , or SMAD4 , alone or in combination, with or without TGFβ1. ( E ) Snapshot of the UCSC genome browser showing predicted SMAD-binding regions in LINC00313 gene locus, using the JASPAR CORE 2022 collection. Active histone mark (H3K27ac) is also shown around LINC00313 TSS. Data information: Data are presented as mean ± SD ( n = 3 biological replicates). * P ≤ 0.05, ** P ≤ 0.01, *** P ≤ 0.001 (Student’s t -test), n.s.: not significant. In panel ( A ) the experiment in HuCCT1 cells was performed twice ( n = 2 biological replicates) and data are presented as single data points. .

    Article Snippet: The SMAD3 inhibitor (E)-SIS3 (MedChemExpress, HY-13013) was used at a final concentration of 10 µM.

    Techniques: Expressing, Transfection, Binding Assay